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1 lis 2023 · To date, there are several treatments for AD that target telomerase. First, upregulation of telomerase may be a potential strategy for the treatment of AD, as its expression may protect neurons from a Aβ induced cell apoptosis [59]. It has been proven that laminin receptors (LRP/LR) interact with telomerase and are pathologically associated ...
5 sie 2024 · While many studies have examined telomere length (TL) and telomerase activity as prognostic biomarkers in human cancer, this review focuses on potential interactions between inflammation and telomere biology in cancer development.
1 paź 2020 · The aim of this study was to perform a systematic review to evaluate the effect of telomerase activation in the treatment of degenerative and aging disorders. We accomplished the search using the Pubmed interface for papers published from September 1985 to April 16th, 2020.
Background. Although telomerase has potential for age-related disease intervention, the overexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against se in anti-aging telomerase therapeutics. While multiple reviews document the canonical function of telomerase for maintenance of telomeres, as well as an ...
10 lut 2022 · To build a case for the TEDS theory, key aspects of telomere biology, telomere length measurements, and telomere disorders are briefly reviewed, followed by a discussion of cell turnover and telomere erosion in relation to various forms of DNA damage, aging, and cancer.
14 sty 2021 · Telomere attrition and dysfunction causes and consequences of cellular and molecular aging and age-related disease. Mounting data revel how telomeres are entwined with other aging hallmarks and may be therapeutic targets for aging and age-related disease.
24 sty 2024 · As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.
