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4 gru 2020 · We showed that race and age were significantly associated with telomere length in women treated for early stage BC and that acquired telomere alterations differed based on the woman’s treatment regimen.
30 lip 2020 · Here we discuss recent efforts targeting telomerase, including immunotherapies and direct telomerase inhibitors, as well as emerging approaches such as targeting TERT gene expression driven by...
21 lip 2016 · Natural and small-molecule telomerase inhibitors, immunotherapeutic approaches, oligonucleotide inhibitors, and telomerase-directed gene therapy are useful treatment strategies. Telomerase is more widely expressed than any other tumor marker.
7 wrz 2023 · From a technical point of view, there are several strategies for the telomerase-based treatment of cancer: oligonucleotide inhibitors, small-molecule telomerase inhibitors, immunotherapeutic approaches, telomerase-directed gene therapy, phytochemicals and various other substances with off-target effects and a broad range of mechanisms.
5 lip 2022 · Whilst telomerase inhibitors have historically been heralded as promising anticancer agents, the reality has been more challenging, and there are currently no therapeutic options for cancer types...
Here we discuss recent efforts targeting telomerase, including immunotherapies and direct telomerase inhibitors, as well as emerging approaches such as targeting TERT gene expression driven by TERT promoter mutations.
5 sie 2024 · While many studies have examined telomere length (TL) and telomerase activity as prognostic biomarkers in human cancer, this review focuses on potential interactions between inflammation and telomere biology in cancer development.
