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1. www.ncbi.nlm.nih.gov › pmc › articlesTel-eVax: a genetic vaccine targeting telomerase for treatment of...

   www.ncbi.nlm.nih.gov › pmc › articles

   11 gru 2018 · Tel-eVax in combination with CHOP is safe and immunogenic in lymphoma canine patients. These data confirm the therapeutic efficacy of dTERT vaccine and hold promise for the treatment of dogs affected by other cancer types. More importantly, our findings may translate to human clinical trials and represent new strategies for cancer treatment.

2. www.ncbi.nlm.nih.gov › pmc › articlesSafety and Efficacy of a Genetic Vaccine Targeting Telomerase...

   www.ncbi.nlm.nih.gov › pmc › articles

   31 lip 2013 · They show that treating dogs with an adenovirus/DNA-based genetic vaccine targeting dog telomerase (dTERT) is safe and has a significant impact on the survival of LSA canine patients when combined with chemotherapy, compared with dogs treated by chemotherapy alone.

3. pubmed.ncbi.nlm.nih.gov › 23902422Safety and efficacy of a genetic vaccine targeting telomerase...

   pubmed.ncbi.nlm.nih.gov › 23902422

   We have recently shown that a genetic vaccine targeting dog telomerase reverse transcriptase (dTERT) and based on adenovirus DNA electro-gene-transfer (Ad/DNA-EGT) technology can induce strong cell-mediated immune responses against this tumor antigen and increase overall survival of dogs affected by B-cell lymphosarcoma (LSA) in comparison with ...

4. www.ncbi.nlm.nih.gov › pmc › articlesA DNA telomerase vaccine for canine cancer immunotherapy

   www.ncbi.nlm.nih.gov › pmc › articles

   5 maj 2019 · New therapeutic veterinary approaches are greatly needed. One of the few novel products to come onto the pet market is DNA vaccination targeting the tumor associated antigen (TAA) canine tyrosinase. Xenogeneic DNA vaccines were designed to bypass central immune tolerance.

5. www.cell.com › molecular-therapy-family › molecular-therapyA Vaccine Targeting Telomerase Enhances Survival of Dogs ... -...

   www.cell.com › molecular-therapy-family › molecular-therapy

   Therefore, dog TERT (dTERT) can constitute a valid target for translational cancer immunotherapy. We have evaluated the ability of adenovirus serotype 6 (Ad6) and DNA electroporation (DNA-EP) to induce immune responses against dTERT in dogs affected by malignant lymphoma (ML).

6. link.springer.com › content › pdfTel-eVax: a genetic vaccine targeting telomerase for treatment of...

   link.springer.com › content › pdf

   Dogs developed antibodies against the immunizing antigen. Conclusions: Tel-eVax in combination with CHOP is safe and immunogenic in lymphoma canine patients. These data confirm the therapeutic eficacy of dTERT vaccine and hold promise for the treatment of dogs afected by other cancer types.

7. jitc.bmj.com › content › 1Safety and efficacy of a genetic vaccine targeting Telomerase...

   jitc.bmj.com › content › 1

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   We have recently shown that a genetic vaccine targeting dog telomerase (dTERT) and based on Ad/DNA-EGT technology can induce strong cell-mediated immune responses against this tumor antigen and increase overall survival of dogs affected by B-cell lymphosarcoma (LSA) in comparison with historical controls when combined with COP chemotherapy regimen.