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1. www.nature.com › articles › s41556/022/00842-xTelomere dysfunction in ageing and age-related diseases

   www.nature.com › articles › s41556/022/00842-x

   14 lut 2022 · A total of 33% of women and 20% of men over the age of 50 years are estimated to experience osteoporosis-related fractures. Increasing evidence points towards a role for telomere...

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2. www.sciencedirect.com › science › articleDistinct roles of telomerase activity in age-related chronic...

   www.sciencedirect.com › science › article

   1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.

3. www.frontiersin.org › journals › agingFrontiers | Unlocking longevity: the role of telomeres and its...

   www.frontiersin.org › journals › aging

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   24 sty 2024 · Telomerase gene therapy is an emerging approach that seeks to address cellular aging by directly modulating telomerase activity in cells. In an in vivo study conducted in mice, telomerase gene therapy using an adeno-associated virus to express TERT led to significant health improvements and reduced aging markers without elevating cancer incidence.

4. med.stanford.edu › news › all-newsTelomere extension turns back aging clock in cultured human cells...

   med.stanford.edu › news › all-news

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   22 sty 2015 · This new approach paves the way toward preventing or treating diseases of aging. The researchers found that as few as three applications of the modified RNA over a period of a few days could significantly increase the length of the telomeres in cultured human muscle and skin cells.

5. onlinelibrary.wiley.com › doi › fullTelomere length and aging‐related outcomes in humans: A Mendelian...

   onlinelibrary.wiley.com › doi › full

   24 sie 2019 · Telomerase activation may treat aging-related diseases and prolong human lifespan (de Jesus & Blasco, 2013). Previous studies on adult or old mice have shown successes from improving physical function and lifespan without increasing incidence of cancer, but the translation from mice to humans is unknown (de Jesus & Blasco, 2013).

6. link.springer.com › article › 10Evaluation of potential aging biomarkers in healthy individuals...

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   31 lip 2023 · We selected potential biomarkers of aging - telomerase, AGEs, GDF11 and 15 (growth differentiation factor 11/15), sirtuin 1, NAD + (nicotinamide adenine dinucleotide), inflammasome NLRP3, DNA/RNA damage, and klotho to investigate changes in their levels depending on age and sex.

7. www.embopress.org › doi › fullTelomerase gene therapy: a novel approach to combat aging

   www.embopress.org › doi › full

   15 maj 2012 · Promoting healthspan in mice using a telomerase gene therapy. Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.