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1. www.nature.com › articles › s41556/022/00842-xTelomere dysfunction in ageing and age-related diseases

   www.nature.com › articles › s41556/022/00842-x

   14 lut 2022 · Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere...

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2. www.sciencedirect.com › science › articleDistinct roles of telomerase activity in age-related chronic...

   www.sciencedirect.com › science › article

   1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.

3. www.cell.com › cell › fulltextTelomeres: history, health, and hallmarks of aging - Cell Press

   www.cell.com › cell › fulltext

   14 sty 2021 · Telomere attrition and dysfunction causes and consequences of cellular and molecular aging and age-related disease. Mounting data revel how telomeres are entwined with other aging hallmarks and may be therapeutic targets for aging and age-related disease.

4. www.ncbi.nlm.nih.gov › pmc › articlesTelomere-associated aging disorders - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   23 lut 2023 · These disorders have overlapping symptoms and a common underlying mechanism of telomere dysfunction, but also exhibit variable symptoms and age of onset, suggesting they fall along a spectrum of disorders.

5. www.ncbi.nlm.nih.gov › pmc › articlesTelomerase in Brain: The New Kid on the Block and Its Role in ...

   www.ncbi.nlm.nih.gov › pmc › articles

   29 kwi 2021 · The establishment of a protective effect of telomerase in brain and neurons has prompted several groups to employ experimental interventions in order to increase TERT levels. This could benefit brain function like cognition during ageing as well as pose a therapeutic option for treating neurodegenerative diseases. 5.1.

6. www.mdpi.com › 1422/0067/25-15 › 8542Aging, Cancer, and Inflammation: The Telomerase Connection - MDPI

   www.mdpi.com › 1422/0067/25-15 › 8542

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   5 sie 2024 · By enhancing telomerase activity, it may be possible to preserve telomere length, reduce cellular senescence, and promote tissue regeneration, thereby alleviating symptoms and progression of diseases associated with aging, such as cardiovascular diseases, neurodegenerative disorders, and diabetes .

7. www.ncbi.nlm.nih.gov › pmc › articlesTherapeutic Targeting of Telomerase - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   21 lip 2016 · The association between telomere length and aging has also led to the development of telomerase activators that may induce hTERT and/or hTR expression, enhance enzyme activity and/or influence cellular location. The idea behind this approach is to reverse normal cellular aging and to treat symptoms of aging.