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2 wrz 2024 · Researchers have shown that restoring youthful levels of a telomerase subunit can significantly alleviate aging signs in models, potentially impacting age-related diseases like Alzheimer’s and cancer.
15 maj 2012 · Promoting healthspan in mice using a telomerase gene therapy. Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.
5 sie 2024 · By enhancing telomerase activity, it may be possible to preserve telomere length, reduce cellular senescence, and promote tissue regeneration, thereby alleviating symptoms and progression of diseases associated with aging, such as cardiovascular diseases, neurodegenerative disorders, and diabetes .
1 lis 2023 · Considering that aging is the most important risk factor for neurodegenerative and metabolic diseases, this article will analyze the evidence, mechanism, and therapeutic potential of telomerase activity in several chronic disease, including type 2 diabetes, neurodegenerative diseases, atherosclerosis, heart failure and non-alcoholic fatty liver ...
16 maj 2017 · Studies have demonstrated a direct correlation between telomere length and life expectancy, stress, DNA damage, and onset of aging-related diseases. This review discusses the most important factors that influence our telomeres.
10 lut 2022 · To build a case for the TEDS theory, key aspects of telomere biology, telomere length measurements, and telomere disorders are briefly reviewed, followed by a discussion of cell turnover and telomere erosion in relation to various forms of DNA damage, aging, and cancer.
4 paź 2012 · A rapidly growing body of research suggests that one snapshot measure of leukocyte telomere length is predictive of age-related physiologic decline, onset of diseases of aging, such as cancer and dementia, and early mortality (1–3).
