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1. www.nature.com › articles › s41556/022/00842-xTelomere dysfunction in ageing and age-related diseases

   www.nature.com › articles › s41556/022/00842-x

   14 lut 2022 · Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere...

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2. www.sciencedirect.com › science › articleDistinct roles of telomerase activity in age-related chronic...

   www.sciencedirect.com › science › article

   1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.

3. www.ncbi.nlm.nih.gov › pmc › articlesTelomere-associated aging disorders - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   23 lut 2023 · These disorders have overlapping symptoms and a common underlying mechanism of telomere dysfunction, but also exhibit variable symptoms and age of onset, suggesting they fall along a spectrum of disorders.

4. www.mdpi.com › 1422/0067/25-15 › 8542Aging, Cancer, and Inflammation: The Telomerase Connection - MDPI

   www.mdpi.com › 1422/0067/25-15 › 8542

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   5 sie 2024 · By enhancing telomerase activity, it may be possible to preserve telomere length, reduce cellular senescence, and promote tissue regeneration, thereby alleviating symptoms and progression of diseases associated with aging, such as cardiovascular diseases, neurodegenerative disorders, and diabetes .

5. pmc.ncbi.nlm.nih.gov › articles › PMC7403649Telomerase Biology Associations Offer Keys to Cancer and Aging...

   pmc.ncbi.nlm.nih.gov › articles › PMC7403649

   Background. Although telomerase has potential for age-related disease intervention, the overexpression of telomerase in about 90% of cancers, and in HIV virus reservoirs, cautions against se in anti-aging telomerase therapeutics. While multiple reviews document the canonical function of telomerase for maintenance of telomeres, as well as an ...

6. www.frontiersin.org › journals › agingFrontiers | Unlocking longevity: the role of telomeres and its...

   www.frontiersin.org › journals › aging

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   24 sty 2024 · As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.

7. www.ncbi.nlm.nih.gov › pmc › articlesTelomeres and aging: on and off the planet! - PMC - National...

   www.ncbi.nlm.nih.gov › pmc › articles

   6 kwi 2024 · Telomerase-based gene therapy also has potential for improving treatment of specific age-related degenerative diseases, including Alzheimer’s (e.g., Telocyte).