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1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
24 sty 2024 · As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.
Telomerase activity can be restored to human cells by hTERT gene transduction or potentially via drug therapy; such extended-lifespan cells could be useful in forms of cell therapy to be developed for age-related diseases.
14 lut 2022 · Senescent cells accumulate with age in the murine brain and is exacerbated in late-generation telomerase-deficient mice 150, which suggests a causal role for telomere dysfunction in this...
In this review, we describe the changes in telomerase and telomere length (TEL) during development, their role in carcinogenesis processes, and the consequences of reduced telomerase activity. More specifically, the connection of TEL in peripheral blood cells with the development of aging-associated diseases is discussed.
Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify or drive molecular biological processes underlying each hallmark of aging and contribute to the development of age-related diseases such as neurodegeneration and cancer.
Telomeres are hallmarks and molecular drivers of aging, as well as fundamental integrating components of the cumulative effects of genetic, lifestyle, and environmental factors that erode telomere length over time.
