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5 lip 2022 · Whilst telomerase inhibitors have historically been heralded as promising anticancer agents, the reality has been more challenging, and there are currently no therapeutic options for cancer types...
14 cze 2024 · A telomerase inhibitor that can shorten telomeres of malignant cells, leading to their apoptosis, could help patients, hypothesized Geron. The company focused initially on patients with low- to...
20 paź 2020 · Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two...
Anticancer approaches directed at telomerase inhibition are varied, and methods ranging from RNA interference (RNAi) of the TERT catalytic subunit to inhibition of the proteins associated with telomerase at the telomeres have proven to have efficacy against cancer.
7 wrz 2023 · The figure summarizes the traditional and novel strategies for telomerase-based treatment of cancer: (1) oligonucleotide inhibitors inhibiting telomerase by binding to the mRNA of telomerase components and to turn the gene "off" (1A) or by inactivating the RNA template of the telomerase complex (1B), (2) alternative splicing to induce splicing ...
20 cze 2016 · Studies using telomerase inhibition strategies have established that robust hTERT inhibition can lead to progressive telomere shortening and eventually cancer cell death. Several approaches, including use of small-molecule inhibitors, antisense oligonucleotides, immunotherapy, and G-quadruplex stabilizers have been employed to inhibit ...
Here we discuss recent efforts targeting telomerase, including immunotherapies and direct telomerase inhibitors, as well as emerging approaches such as targeting TERT gene expression driven by TERT promoter mutations.
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