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10 kwi 2023 · Tamoxifen is a selective estrogen receptor modulator (SERM) medication used to treat breast cancer in men and women and as a prophylactic agent against breast cancer in women.
Over 20 years of use have made tamoxifen one of the most studied anti-cancer drugs (Jordan, 1993), and it is associated with less toxicity than other current endocrine treatments for breast cancer .
10 kwi 2023 · Tamoxifen is indicated for the treatment of breast cancer in a variety of settings. It should be noted that evidence suggests that patients with estrogen receptor-positive tumors are more likely to benefit from tamoxifen.
1 sty 2018 · Tamoxifen is considered a pioneering drug due to its ubiquitous use in both treatment and chemoprevention of breast cancer and also for research addressing novel selective estrogen receptor modulators (SERMs).
Tamoxifen has been used as the first-line therapy for hormone-responsive male breast cancer, and is also used as adjuvant therapy for estrogen receptor- or progesterone receptor-positive male breast cancer. Tamoxifen has also been used for anovulatory infertility.
Studies in the adjuvant setting have shown that endocrine therapy related side effects predict breast cancer recurrence risk. Here, we assess the relationship between early reported side effects and incidence of breast cancer in women randomised to tamoxifen for cancer prevention in the International Breast Intervention Study (IBIS)–I trial.
30 gru 2015 · Tamoxifen is a selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
