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20 sie 2020 · Current indications include both treatment of breast cancer and reduction of breast cancer risk in women at high risk. Tamoxifen is available in 10 and 20 mg tablets generically and under several trade names such as Nolvadex and Tamone. Tamoxifen is also available as an oral solution (10 mg/5 mL).
10 kwi 2023 · Tamoxifen is a selective estrogen receptor modulator (SERM) medication used to treat breast cancer in men and women and as a prophylactic agent against breast cancer in women.
For reduction in the incidence of breast cancer in women at high risk, the recommended dosage of tamoxifen is 20 mg daily given for 5 years. For the treatment of advanced (metastatic) breast cancer in men, the usual dosage of tamoxifen is 20–40 mg daily.
10 kwi 2023 · This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, toxicity, and monitoring, of tamoxifen, so providers can direct patient therapy in treating indicated disorders as part of the interprofessional team.
However, both in trials of 5 years of tamoxifen 1 and in ATLAS, there was a difference of only about 80% between the prevalence of tamoxifen use in the two treatment groups, so the estimates in table 3 are likewise of what would be seen in trials of 10 years of tamoxifen compared with no tamoxifen that had only about 80% compliance. The risk ...
Steady-state trough concentrations were measured of tamoxifen, N-desmethyltamoxifen, 4-hydroxy-tamoxifen, and endoxifen. CYP2D6 and CYP3A4 phenotypes were assessed for all patients by genotyping. Multiple linear regression models were used to analyze tamoxifen and endoxifen variability.
Three endoxifen thresholds have been suggested (5.9 ng/ml, 5.2 ng/ml and 3.3 ng/ml) for therapeutic drug monitoring (TDM). Our aim was to validate these thresholds and to examine endoxifen exposure with clinical outcome in early-breast cancer patients using tamoxifen.
