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10 kwi 2023 · Tamoxifen is a selective estrogen receptor modulator (SERM) medication used to treat breast cancer in men and women and as a prophylactic agent against breast cancer in women.
In this analysis, in normal CYP2D6 metabolizers, Ki67 did show a significant reduction after administration of tamoxifen 10 mg weekly, likely because patients with a normal CYP2D6 function reach higher endoxifen levels than poor or intermediate metabolizers.
21 gru 2021 · Tamoxifen is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans. Cancer Studies in Humans. Data from epidemiological studies and clinical trials indicate a causal relationship between exposure to tamoxifen and cancer of the uterus (endometrial type).
For the treatment of metastatic breast cancer in women, the usual dosage of tamoxifen is 20–40 mg daily, typically starting with the 20 mg dose. Dosages exceeding 20 mg daily are typically given in divided doses (morning and evening). A 20 mg oral dose is administered as 10 mL of the oral solution.
10 kwi 2023 · Tamoxifen is indicated for the treatment of breast cancer in a variety of settings. It should be noted that evidence suggests that patients with estrogen receptor-positive tumors are more likely to benefit from tamoxifen.
Here, we assess the relationship between early reported side effects and incidence of breast cancer in women randomised to tamoxifen for cancer prevention in the International Breast Intervention Study (IBIS)–I trial.
29 gru 2023 · Previous reports have evidenced that tamoxifen (Tam) induces autophagy and activates transcription factor EB (TFEB), which regulates the expression of genes controlling autophagy and lysosomal biogenesis.
