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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional modifications (part A ), circular RNA (circRNA) mechanisms (part B) and novel uses of RNA scaffolds (part C ).
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
4 sty 2022 · RNA devices spanning research, biomanufacturing and clinical uses. We then review advances in expanding ana-lyte sensing and mechanisms of action with engineered RNA.
4 sty 2022 · Herein, we present a generalizable and versatile strategy to engineer synthetic DNA ligand-binding devices that can be programmed to load and release a specific ligand at a defined...
1 gru 2015 · Increasingly, these novel synthetic biology tools are exploiting the extensive programmable nature of RNA, vis-à-vis DNA- and protein-based devices, to rationally design standardized, composable, and orthogonal parts, which can be scaled and tuned promptly and at will.
1 paź 2015 · We review recent progress in RNA synthetic biology. • New advances in synthetic RNA regulator design have created high-performing/functioning parts. • New generation of RNA parts are being applied to a range of applications. • Experimental and computational tools are aiding a new era of RNA design.
