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4 sty 2022 · RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics...
In this Review, we discuss current applications of RNA devices spanning research, biomanufacturing and clinical uses. We then review advances in expanding analyte sensing and mechanisms of action with engineered RNA.
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
14 kwi 2024 · This enables the design of RNA-sensing systems that can help to identify specific cell types, but also manipulate cell fate in a cell type-specific manner. Synthetic devices can be engineered that sense the cellular level of a transcript, such as miRNAs, and reprogram the output depending on the miRNA signature of the cell [Citation 7].
4 sty 2022 · RNA devices spanning research, biomanufacturing and clinical uses. We then review advances in expanding ana-lyte sensing and mechanisms of action with engineered RNA.
19 maj 2017 · However, the number of available devices is limited due to the difficulty in the detection of endogenous proteins within a cell. Here, we show a strategy to construct synthetic mRNA devices that detect endogenous proteins in living cells, control translation and distinguish cell types.
23 sty 2023 · Here, we review both existing and emerging DNA synthesis technologies, with an emphasis on methodologies developed in industry as a means to accelerate the supply of long synthetic DNA.
