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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This...
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RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
19 maj 2017 · However, the number of available devices is limited due to the difficulty in the detection of endogenous proteins within a cell. Here, we show a strategy to construct synthetic mRNA devices that detect endogenous proteins in living cells, control translation and distinguish cell types.
4 sty 2022 · This apta-FRET system reports on RNA con-formational changes and offers a general tool for stud-ying the folding and conformational changes of natural and artificial RNA structures in vivo.
17 sty 2022 · Synthetic DNA is the basis for promising technologies in data storage, barcoding, computing 62 and sercurity. In this review, the authors provide an overview of the field and its future.
3 lip 2023 · Here we report an RNA-based synthetic circuit that can establish regulatory linkages between expression of endogenous genes in both Escherichiacoli and mammalian cells. This design employs a displacement–assembly approach to modulate the activity of guide RNA for function control of CRISPR/Cas9.
15 lis 2013 · Synthetic regulatory RNAs can statically and dynamically control gene expression. We review current developments in the design of synthetic regulatory RNAs. We review applications of synthetic RNA tools in biological systems design.
