Search results
4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses the...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
4 sty 2022 · Components of synthetic RNA devices. A major research focus in synthetic biology is the devel-opment of modular frameworks for constructing geneti-cally encoded devices and engineered...
19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
23 wrz 2019 · Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in...
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
We review recent advances in the design and expression of synthetic RNA sequences inside cells, to regulate gene expression and to achieve spatial localization of components.
