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4 sty 2022 · Here, we describe recent advances that address these limitations and point to a significant maturation of synthetic RNA-based devices. Synthetic RNA devices integrate sensing,...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
23 wrz 2019 · Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in...
19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
4 sty 2022 · Leveraging the dependence of the CRISPR system on a guide RNA (gRNA), researchers designed a control system that incorporates small molecule-responsive aptamers into the 3′ region of the gRNA...
19 maj 2017 · Here, we show a strategy to construct synthetic mRNA devices that detect endogenous proteins in living cells, control translation and distinguish cell types.
3 lip 2023 · This study provides an effective pathway towards construction of regulatory connections between endogenous genes through synthetic RNA circuits, which can introduce new signal pathways and cellular responses into genetic networks of mammalian cells.
