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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour....
Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional modifications (part A ), circular RNA (circRNA) mechanisms (part B) and novel uses of RNA scaffolds (part C ).
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
17 godz. temu · Prime editors are another complementary technology; these tools are RNA-guided DNA editors that use a reverse transcriptase to directly write DNA into a target site from an encoded RNA template ...
1 gru 2022 · This review summarizes our current understanding of RNA editing in various organisms especially focusing on C-to-U and U-to-C RNA editing in plants and pentatricopeptide repeat (PPR) proteins that are responsible for target RNA recognition and editing reactions.
5 maj 2006 · Researchers in synthetic biology have assembled ncRNAs that couple riboswitch-like aptamer domains with antisense effector domains to create gene expression tools. Bayer and Smolke recently ...
19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
