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Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional modifications (part A ), circular RNA (circRNA) mechanisms (part B) and novel uses of RNA scaffolds (part C ).
4 sty 2022 · Recent findings have revealed new roles and mechanisms for RNA beyond control of translation through the central dogma, including targeted RNA base editing and post-transcriptional...
1 gru 2022 · This review summarizes our current understanding of RNA editing in various organisms especially focusing on C-to-U and U-to-C RNA editing in plants and pentatricopeptide repeat (PPR) proteins that are responsible for target RNA recognition and editing reactions.
29 gru 2021 · A DNA-editing all-in-one RNA-guided CRISPR-Cas transposase (DART) process has also been developed that is capable of generating organism- and location-specific insertions within natural communities (Rubin et al., 2020).
11 lip 2019 · This special issue of Genes on “Synthetic DNA and RNA Programming” features 12 original research articles and reviews that highlight novel aspects of basic molecular and cellular biology, uncovered by the application and development of synthetic biology-driven approaches.
14 lip 2022 · RNA-guided nuclease for robust gene editing. The CRISPR-Cas9 nuclease system is inherently simple, requiring only two components—a RNA portion that ‘guides’ a Cas9 endonuclease to the loci of interest where it triggers endogenous DNA repair pathways to facilitate site-specific genome modifications.
1 cze 2020 · Synthetic RNA molecules expressed within cells can be optimized for a variety of tasks that include control of gene expression and organization of small molecules and proteins. Here, we review recent research advances that exploit RNA structure for synthetic biology applications.
