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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
RNA devices integrate cellular information sensing, processing and actuation of specific signals into defined functions and have yielded programmable biological systems and novel therapeutics of increasing sophistication.
19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
5 maj 2006 · Researchers in synthetic biology have assembled ncRNAs that couple riboswitch-like aptamer domains with antisense effector domains to create gene expression tools. Bayer and Smolke recently ...
4 sty 2022 · Leveraging the dependence of the CRISPR system on a guide RNA (gRNA), researchers designed a control system that incorporates small molecule-responsive aptamers into the 3′ region of the gRNA...
9 wrz 2011 · We will review the rapidly growing field of RNA synthetic biology as it transitions from the molecular design of RNA-based genetic parts and devices to the implementation of these elements in genetic systems for programming complex biological behaviors.
3 lip 2023 · This study provides an effective pathway towards construction of regulatory connections between endogenous genes through synthetic RNA circuits, which can introduce new signal pathways and cellular responses into genetic networks of mammalian cells.
