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4 sty 2022 · Nature Reviews Genetics - Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses...
23 wrz 2019 · Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in...
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19 maj 2017 · Synthetic mRNA devices with RNA-binding proteins have been applied to construct cellular logic gates and to control cell fate (25, 46). The direct detection of human endogenous proteins by synthetic RNAs may open the door to program cell fate autonomously based on intracellular protein information.
19 lis 2018 · Thus, we aimed to design synthetic RNA-delivered logic circuits that function in mammalian cells by improving the performance of miRNA- and protein-responsive modRNAs.
1 gru 2021 · To provide safer synthetic biology products, RNA has recently emerged as an alternative to DNA to deliver transgenes into mammalian cells. In this review, we discuss recent tools implemented to engineer programmable RNA-based synthetic circuits in mammalian cells.
