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2 dni temu · Main text. Although hydrogen sulfide (H 2 S) was recognized historically as a highly toxic gas, it has since emerged as an important regulator of various biological processes, including vasodilation, neurotransmission, and cellular respiration. 2 These physiological effects are thought to be mediated primarily by H 2 S generated endogenously in ...
10 maj 2023 · The review summarizes the current knowledge on the mechanisms of ISC biogenesis, the role of ISC modulation in ferroptosis, and the potential of targeting ISCs for cancer therapy. The review provides insight into new therapeutic strategies for cancer treatment based on regulating ISC metabolism.
16 cze 2023 · Sulforaphane can also be used with conventional cancer treatments to achieve an enhanced effect. The group of Małgorzata Milczarek shed light on the development of new combinations by conducting an in vitro study. The data unveiled that the combination of sulforaphane and fluorouracil is more effective in enhancing the process of apoptosis ...
21 cze 2024 · SFN treatment increases the levels of cleaved Caspase-3 and Bax, decreases the levels of Bcl-2, generates ROS to induce apoptosis in glioblastoma cells, and exerts anticancer effects by inhibiting the activation of the STAT3 signaling pathway in cancer cells (Miao et al. 2017).
25 wrz 2020 · In this study, we aimed to investigate the gene expression profile in hepatocellular carcinoma (HCC) and the effects of reactive sulfur species (RSS) on HCC tumor cells. Furthermore, the cell imaging technology was applied to discover some potential anti-cancer compounds.
23 lip 2017 · Treatment of breast ductal carcinoma in situ stem-like subpopulations with SFN increased exosomal miR-140 and decreased miR-21 and miR-29. In addition, SFN decreased colony formation and ALDH1 expression.
23 lip 2017 · There has been extensive research on combination therapy for cancer treatment; for instance, bevacizumab in combination with an absorbable curcumin resulted in a reduction in tumor growth and inhibition of angiogenesis in HT29 colonic cancer cells (Yue et al. 2016).
