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16 mar 2012 · Here, we review recent advances in HIV-1 structural biology, focusing on the molecular mechanisms of viral replication and on the development of new therapeutics. Schematic overview of the...
The infection begins when envelope glycoprotein spikes engage the CD4 receptor and the membrane spanning co-receptor (step 1; cell proteins discussed in text are indicated in green type), which leads to viral–cell membrane fusion and entry of the virus particle into the cell (step 2).
its deceptive simplicity: HIV‑1 can persistently infect humans by subverting the innate and adaptive immune systems, despite encoding only 15 mature proteins.
16 mar 2012 · Key Points. HIV-1 replication relies on the proper functioning of specific viral proteins, three of which — protease, integrase, and reverse transcriptase with associated RNase H activity —...
10 maj 2024 · Human immunodeficiency virus type 1 (HIV-1) remains a serious health threat in Indonesia. In particular, the CRF01_AE viruses were the predominant HIV-1 strains in various cities in Indonesia.
29 sty 2021 · The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions...
HIV-1 assembles into morphologically distinct immature and mature virions. The virus initially assembles and buds from cells as a noninfectious, immature spherical particle that is organized by a layer of Gag proteins that are associated with the inner viral membrane ( Fig. 1 ).
