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Although the selective serotonin reuptake inhibi-tors (SSRIs) have better overall safety and toler-ability than older antidepressants, broad-based experience with SSRIs has shown the frequency and type of side effects to be increased relative to clinical trial data.
1 maj 2023 · Common side effects from SSRIs include sexual dysfunction, sleep disturbances, weight changes, anxiety, dizziness, xerostomia, headache, and gastrointestinal distress. SSRIs also have the potential to prolong the QT interval, which can lead to fatal arrhythmia, torsade de pointes.
Sexual side effects are common with most antidepressants. Bupropion and mirtazapine may be least problematic. Many antidepressants are substrates of CYP450 enzymes. See our Cytochrome P450 Drug Interactions chart to help check for interactions. --absent or rare to ++++ relatively common.
The most common side effects of SSRIs are nausea, headaches, decreased sex drive, and feeling “jittery.” Some patients also have noticed fatigue and difficulty sleeping. Many side effects go away after taking the medication consistently for 1-2 weeks.
Comparison of antidepressant medications and their possible side effects. This table shows which side effects are seen with different antidepressants. The more dots there are, the more important a side effect is: Graphic 143603 Version 1.0.
Common side effects • Headache, nausea, diarrhea, dry mouth, increased sweating • Feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia)
Psychiatric side effects of SSRIs have been grouped into the mania spectrum (mania, hypomania, elevated mood), depression spectrum (aggravation of depression, crying, irritability, anger, hypersensitivity),
