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The clinical course of ALF is initiated with a severe ALI. This is characterised by a two- to threetimes elevation of transaminases (as a marker of liver damage) associated with impaired liver function, i.e., jaundice and coagulopathy, in a patient without a chronic liver disease.
Herein, we provide the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for the evaluation of liver disease severity and prognosis, focusing on the topics for which relevant evidence has been published in the last 5 years.
15 lut 2022 · Key points. Two-step risk stratification with non-invasive tests (NITs) of patients with risk factors for liver disease in the general population setting has high diagnostic accuracy for detecting fibrosis.
26 sty 2017 · Liver function tests (LFTs) are routinely used to screen for liver disease. A correct interpretation of LFT abnormalities may suggest the cause, severity, and prognosis of an underlying disease. Once the diagnosis has been established, sequential LFT assessment can be used to assess treatment efficacy.
20 gru 2022 · Whenever possible, patients with acute liver failure should be managed in an intensive care unit at a liver transplantation center. This topic will review the etiology, clinical manifestations, and diagnosis of acute liver failure in adults.
20 mar 2023 · Subacute liver failure (SALF): 4-12 weeks from jaundice to encephalopathy. Indicates a smouldering disease process. This is less likely to cause cerebral edema or cause immediate death. Clinically this disease process may mimic cirrhosis (e.g., a gradual process with ascites and splenomegaly).
30 maj 2024 · Acute liver failure refers to the development of severe acute liver injury with encephalopathy and impaired synthetic function (international normalized ratio [INR] of ≥1.5) in a patient without cirrhosis or pre-existing liver disease [1,2].
