Search results
24 gru 2019 · To systematically identify somatic mutations in the human body and to investigate their distribution and functional impact, we developed a method that leverages the genomic information carried by RNA to identify DNA somatic mutations while avoiding most sources of false positives.
25 sie 2021 · The human body is composed of somatic and germline cells. Mutations acquired in somatic cells during a lifespan, and their consequences, are restricted to the individual in whom they occur.
24 gru 2019 · These findings reveal fundamental patterns of tissue-specific somatic evolution and shed light on aging and the earliest stages of tumorigenesis.
14 wrz 2021 · Four new studies in Nature report multi-tissue analyses of somatic mutations from human donors, with insights into cell lineage commitment during embryonic development, as well as...
25 sie 2021 · Somatic mutations that accumulate in normal tissues are associated with ageing and disease 1, 2. Here we performed a comprehensive genomic analysis of 1,737 morphologically normal tissue...
25 wrz 2015 · From zygote to adult, a human undergoes trillions of cell divisions, with somatic mutations accumulating at each division. Tissues such as epithelial cells divide throughout life, and even terminally differentiated tissues continue to acquire somatic mutations through nonreplicative processes.
3 lip 2021 · Once we can accurately ascertain the mutation landscape of tissues across hundreds or thousands of individuals, we can unlock the unique potential of somatic mutations to understand disease biology and identify novel drug target candidates.
