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11 paź 2024 · Abstract. Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are...
7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
3 lip 2021 · We and two Japanese groups have recently shown that cells from the mucosal epithelium of IBD patients frequently carry somatic mutations in PIGR and genes in Toll-like receptor (TLR) and interleukin-17 (IL-17) pathways, most notably NFKBIZ and ZC3H12A .
28 mar 2024 · Somatic mutations originate in a single cell and are propagated within an individual by DNA replication and cell division 2, 3, 4, 5, 6 (Fig. 1b).
Mutations can be grouped into two main categories based on where they occur: somatic mutations and germ-line mutations. Somatic mutations take place in non-reproductive cells.
Somatic evolution of cells within the body is well known to lead to cancers. However, spread of somatic mutations within a tissue over time may also contribute to the pathogenesis of non-neoplastic diseases.
