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  1. www.nature.com › articles › s41576/021/00376-2The origin of human mutation in light of genomic data

    23 cze 2021 · Somatic mutations can be found by deep sequencing 19,20,21,22,23, single-cell sequencing 24 or clonal passage of individual cells 25,26. In cancer, somatic mutations accumulated in cells...

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  2. www.nature.com › articles › s41586/021/03822-7The mutational landscape of human somatic and germline cells

    25 sie 2021 · The human body is composed of somatic and germline cells. Mutations acquired in somatic cells during a lifespan, and their consequences, are restricted to the individual in whom they occur.

  3. www.ncbi.nlm.nih.gov › pmc › articlesSomatic mutation: What shapes the mutational landscape of normal...

    7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.

  4. genomebiology.biomedcentral.com › articles › 10The somatic mutation landscape of the human body

    24 gru 2019 · We used a 1536-type mutation profile including two base-pairs upstream and downstream of the mutation site (pentanucleotide profile).

  5. en.wikipedia.org › wiki › Somatic_mutationSomatic mutation - Wikipedia

    A somatic mutation is a change in the DNA sequence of a somatic cell of a multicellular organism with dedicated reproductive cells; that is, any mutation that occurs in a cell other than a gamete, germ cell, or gametocyte.

  6. www.ncbi.nlm.nih.gov › books › NBK557896Genetics, Somatic Mutation - StatPearls - NCBI Bookshelf

    17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.

  7. www.nature.com › articles › s41576/024/00709-xGenetic variation across and within individuals - Nature

    28 mar 2024 · Somatic mutations originate in a single cell and are propagated within an individual by DNA replication and cell division 2, 3, 4, 5, 6 (Fig. 1b).