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11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked...
A somatic mutation is a change in the DNA sequence of a somatic cell of a multicellular organism with dedicated reproductive cells; that is, any mutation that occurs in a cell other than a gamete, germ cell, or gametocyte.
7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
3 lip 2021 · We and two Japanese groups have recently shown that cells from the mucosal epithelium of IBD patients frequently carry somatic mutations in PIGR and genes in Toll-like receptor (TLR) and interleukin-17 (IL-17) pathways, most notably NFKBIZ and ZC3H12A .
25 sie 2021 · Two ubiquitous mutational signatures, SBS1 and SBS5/40, accounted for the majority of acquired mutations in most cell types, but their absolute and relative contributions varied substantially.
19 lip 2023 · In fitness-suppressors, loss-of-function mutations lead to an increase in cell fitness, whereas in fitness-enhancers, activating mutations lead to greater cell fitness.
