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7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
25 sie 2021 · Laser-capture microdissection and mini-bulk exome sequencing are combined to analyse somatic mutations in morphologically normal tissues from nine organs from five donors, revealing variation...
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a), similar...
13 kwi 2022 · Applying our somatic mutation burden and lifespan data, this implies that the somatic mutation rate per cell division in a mouse is around 1.5- to 8.4-fold higher than in a human.
1 paź 2021 · Positive selection dominates evolution in somatic tissues. Most somatic mutations are thought to be silent, with minimal phenotypic consequences. However, a small minority of mutations will affect the biology of the cell, either in a way that is selectively neutral or that subjects it to natural selection.
6 lip 2022 · Recent advances in sequencing have found somatic mutations in all epithelial tissues studied to date. Here we review how the mutational landscape of normal epithelia is shaped by clonal competition within the stem cell niche combined with environmental exposures.
