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11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to ...
17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.
17 gru 2021 · Most somatic mutations in stem cells of normal tissues are characterized by different contributions of mutational signatures SBS1 and SBS5, but some cells show contributions of signatures caused by tissue-specific endogenous and exogenous exposures.
B: Possible outcomes of a neutral mutation in a crypt stem cell: A new mutation that does not alter stem cell fate (yellow) may generate a clone that is outcompeted by wild type cells and lost or replaces other stem cells so the mutant becomes fixed in the crypt as no non-mutant cells remain. Positively selected mutations confer a greater than ...
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a),...
24 gru 2019 · To gain a better understanding of the genome-wide distribution and functional impact of somatic mutations, we leverage the genomic information contained in the transcriptome to uniformly call somatic mutations from over 7500 tissue samples, representing 36 distinct tissues.
3 lip 2021 · Most somatic mutations are thought to be silent, with minimal phenotypic consequences. However, a small minority of mutations will affect the biology of the cell, either in a way that is selectively neutral or that subjects it to natural selection.
