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7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
17 gru 2021 · From conception to death, human cells accumulate somatic mutations in their genomes. These mutations can contribute to the development of cancer and non-malignant diseases and have also been associated with aging.
11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to ...
25 sie 2021 · Laser-capture microdissection and mini-bulk exome sequencing are combined to analyse somatic mutations in morphologically normal tissues from nine organs from five donors, revealing variation...
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a), similar...
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
3 lip 2021 · Cells that harbor mutations, which enable them to withstand the disease environment while their neighbors perish, can quickly grow to a high frequency in the tissue through a series of bottleneck–expansion cycles (Figure 1 B), as seen in inflammatory bowel disease [26–28] and liver disease [16, 17].
