Search results
17 kwi 2023 · Somatic mutations occurring in cells that generate a growth advantage within the tissue or prohibit cell death are the mutations most at risk for carcinogenesis. Mutations in tumor suppressor genes or proto-oncogenes result in uncontrolled cell division, ultimately leading to a massive accumulation of these mutated cells in the form of a tumor.
Somatic mutation, genetic alteration acquired by a cell that can be passed to the progeny of the mutated cell in the course of cell division. Somatic mutations are frequently caused by environmental factors, such as exposure to ultraviolet radiation or to certain chemicals.
A somatic mutation is a change in the DNA sequence of a somatic cell of a multicellular organism with dedicated reproductive cells; that is, any mutation that occurs in a cell other than a gamete, germ cell, or gametocyte.
7 lip 2022 · From the first division after conception, somatic cells acquire mutations (2–4). This progressive increase in the number of mutations in human stem cells is unavoidable, but on its own cannot explain the diverse mutational landscapes that develop across normal tissues.
11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked...
A somatic mutation is an alteration in DNA which occurs in a somatic cell after conception. Somatic mutations cannot be inherited because they occur in any of the cells of the body except the germ cells.
3 lip 2021 · Positive selection dominates evolution in somatic tissues. Most somatic mutations are thought to be silent, with minimal phenotypic consequences. However, a small minority of mutations will affect the biology of the cell, either in a way that is selectively neutral or that subjects it to natural selection.
