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24 gru 2019 · Our findings paint a complex landscape of somatic mutation across the human body, highlighting their tissue-specific distributions and functional associations.
11 paź 2024 · Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells throughout the body. Somatic mutations are canonically linked to...
24 gru 2019 · Background: Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.
28 mar 2024 · Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between...
25 sie 2021 · Over the course of an individual’s lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples...
17 kwi 2023 · Somatic mutations have received the most study in human carcinogenesis. Various mutations in oncogenes, tumor suppressor genes, and DNA repair mechanisms can select for increased growth advantage and tumor survival. [2]
25 wrz 2015 · From zygote to adult, a human undergoes trillions of cell divisions, with somatic mutations accumulating at each division. Tissues such as epithelial cells divide throughout life, and even terminally differentiated tissues continue to acquire somatic mutations through nonreplicative processes.
