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Somatic mutation, genetic alteration acquired by a cell that can be passed to the progeny of the mutated cell in the course of cell division. Somatic mutations are frequently caused by environmental factors, such as exposure to ultraviolet radiation or to certain chemicals.
A somatic mutation is a change in the DNA sequence of a somatic cell of a multicellular organism with dedicated reproductive cells; that is, any mutation that occurs in a cell other than a gamete, germ cell, or gametocyte.
17 kwi 2023 · A somatic mutation describes any alteration at the cellular level in somatic tissues occurring after fertilization. These mutations do not involve the germline and consequently do not pass on to offspring.
24 gru 2019 · To systematically identify somatic mutations in the human body and to investigate their distribution and functional impact, we developed a method that leverages the genomic information carried by RNA to identify DNA somatic mutations while avoiding most sources of false positives.
25 sie 2021 · We aimed to explore somatic mutations in relatively small populations of cells from specific morphological or functional units, such as endometrial glands or colonic crypts (Fig. 1a), similar...
A somatic mutation is an alteration in DNA which occurs in a somatic cell after conception. Somatic mutations cannot be inherited because they occur in any of the cells of the body except the germ cells. Cancer related somatic mutations can be detected by measuring the alterations between tumor and normal samples.
3 lip 2021 · Once we can accurately ascertain the mutation landscape of tissues across hundreds or thousands of individuals, we can unlock the unique potential of somatic mutations to understand disease biology and identify novel drug target candidates.