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In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.
The compounds most commonly used on the market today as substitutes for common sugar in diet drinks and food products are saccharin, aspartame, and cyclamate. Many fears have arisen around the associated side effects of consuming artificial sweeteners in addition to broader concerns about their safety for human consumption.
It is a salt of cyclohexylsulfamic acid. Sodium cyclamate is used as an NNS, and the analogous calcium salt is used especially in low-sodium diets. Cyclamate is 30 times sweeter than sucrose. It has a bitter aftertaste but has good sweetness synergy with saccharin.
Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration.
Cyclamate (INS 952, E 952) is a calorie-free sweetener discovered in 1937. It is 30 to 50 times sweeter than sucrose. Cyclamate is metabolised to a limited extent by the bacteria in the lower gut by some individuals; limited absorption by the body.
Whether cyclamate has adverse side effects on humans is controversial. Some studies have suggested that very high doses of cyclamate may be associated with bladder cancer or testicular atrophy in some animals, and the U.S. Food and Drug Administration has banned cyclamate from food products.
27 lut 2024 · Like all medicines, this medicine can cause side effects, although not everybody gets them. Frequency not known (frequency cannot be estimated from the available data): Allergic reactions – symptoms include itching, wheezing, rash, swelling of the tongue or throat.
