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In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.
Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [6,7].
Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide. [ 2 ]
27 lis 2017 · Cyclamate (cyclamic acid) is used as an NNS in two forms: sodium cyclamate and calcium cyclamate. It is 30 times sweeter than sucrose and contains zero calories (Chattopadhyay 2014). It is used in more than 50 countries ; however, cyclamate and its salts are currently prohibited from use in the USA .
It is a salt of cyclohexylsulfamic acid. Sodium cyclamate is used as an NNS, and the analogous calcium salt is used especially in low-sodium diets. Cyclamate is 30 times sweeter than sucrose. It has a bitter aftertaste but has good sweetness synergy with saccharin.
Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration.
CYCLAMATE. Cyclamate (INS 952, E 952) is a calorie-free sweetener discovered in 1937. It is 30 to 50 times sweeter than sucrose. Cyclamate is metabolised to a limited extent by the bacteria in the lower gut by some individuals; limited absorption by the body.
