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Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [6,7].
In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.
1 sty 2000 · Article history. PDF. Split View. Cite. Permissions. Share. Abstract. Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
It is a salt of cyclohexylsulfamic acid. Sodium cyclamate is used as an NNS, and the analogous calcium salt is used especially in low-sodium diets. Cyclamate is 30 times sweeter than sucrose. It has a bitter aftertaste but has good sweetness synergy with saccharin.
27 lis 2017 · Cyclamate (cyclamic acid) is used as an NNS in two forms: sodium cyclamate and calcium cyclamate. It is 30 times sweeter than sucrose and contains zero calories ( Chattopadhyay 2014 ). It is used in more than 50 countries ( Fitch 2012 ); however, cyclamate and its salts are currently prohibited from use in the USA ( FDA 2015a ).
