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1. www.health.harvard.edu › blog › sweeteners-time-to-rethink-your-choices-2019022215967Sweeteners: Time to rethink your choices? - Harvard Health

   www.health.harvard.edu › blog › sweeteners-time-to-rethink-your-choices-2019022215967

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   22 lut 2019 · For example, cyclamate (which was often combined with saccharin) was banned from all US food and drink products due to concerns regarding cancer risk. Saccharin's possible link to cancer led to a warning label; as additional research suggested no increased cancer risk in humans, this warning was dropped in 2000.

2. www.ncbi.nlm.nih.gov › pmc › articlesNon‐nutritive sweeteners for diabetes mellitus - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   27 lis 2017 · Cyclamate (cyclamic acid) is used as an NNS in two forms: sodium cyclamate and calcium cyclamate. It is 30 times sweeter than sucrose and contains zero calories (Chattopadhyay 2014). It is used in more than 50 countries ; however, cyclamate and its salts are currently prohibited from use in the USA .

3. pmc.ncbi.nlm.nih.gov › articles › PMC10146554Impact of Long-Term Cyclamate and Saccharin Consumption on...

   pmc.ncbi.nlm.nih.gov › articles › PMC10146554

   No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).

4. www.sciencedirect.com › sodium-cyclamateSodium Cyclamate - an overview | ScienceDirect Topics

   www.sciencedirect.com › sodium-cyclamate

   Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.

5. www.healthline.com › nutrition › artificial-sweeteners-good-or-badArtificial Sweeteners: Good or Bad? - Healthline

   www.healthline.com › nutrition › artificial-sweeteners-good-or-bad

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   28 sie 2024 · Some people may feel bad or experience negative effects after consuming artificial sweeteners, even though they are safe and well tolerated by most people.

6. www.ncbi.nlm.nih.gov › books › NBK533628CYCLAMATES (Group 3) - Overall Evaluations of Carcinogenicity -...

   www.ncbi.nlm.nih.gov › books › NBK533628

   In a single study, eight persons ingesting sodium cyclamate (70 mg/ kg per day) did not exhibit chromosomal aberrations in their lymphocytes 20. Calcium cyclamate induced chromosomal aberrations in bone-marrow cells of gerbils, but not in bone-marrow cells or spermatogonia of rats, treated in vivo.

7. med.libretexts.org › Supplementary_Modules_(Nutrition) › SweetnersCyclamate - Medicine LibreTexts

   med.libretexts.org › Supplementary_Modules_(Nutrition) › Sweetners

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   22 kwi 2024 · Cyclamate was initially marketed as tablets that were recommended for use as a tabletop sweetener for diabetics. In 1958, cyclamates were classified as GRAS (Generally Recognized as Safe). A mixture of cyclamate and saccharin, which had been found to have synergistic sweetening properties and improved taste, was subsequently marketed for use in ...