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After the exclusion of 60 patients according to the exclusion criteria mentioned above, the 181 remaining patients with T2DM and the 82 healthy individuals with an age range between 35 and 70 were enrolled in this study.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
27 lis 2017 · Cyclamate (cyclamic acid) is used as an NNS in two forms: sodium cyclamate and calcium cyclamate. It is 30 times sweeter than sucrose and contains zero calories (Chattopadhyay 2014). It is used in more than 50 countries ; however, cyclamate and its salts are currently prohibited from use in the USA .
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
Urinary tract A 41-year-old woman with anorexia nervosa took large quantities of saccharin and cyclamate and developed polydipsia and polyuria (urine output over 5 l/day) [5 A]. Plasma osmolality was increased (363 mOsm/kg) with a urine osmolality of 388 mOsm/kg, consistent with an osmotic diuresis.
1 sty 2000 · The present study evaluated the long-term toxic and carcinogenic effects of sodium cyclamate on three monkey species. Of the 21 monkeys that were started on cyclamate as newborns in 1970, 14 survived until the study was terminated in 1994.
