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Background: Previous studies on saccharin and cyclamate were either limited to experimental animals or lacked evaluation of their long-term consumption effects in humans. Objectives: This study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 ...
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
3 kwi 2023 · The results suggest that saccharin and cyclamate increased HbA1C (+11.16%), MDA (+52.38%), TG (+16.74%), LDL (+13.39%), and TC/HDL (+13.11%) in healthy volunteers. Diabetic patients consuming sweeteners showed increased FSG (+17.51%), ceruloplasmin (+13.17%), and MDA (+8.92%).
27 lis 2017 · This leads to chronic hyperglycaemia (i.e. elevated plasma glucose levels) and disturbances of carbohydrate, fat, and protein metabolism. In the long term, this condition leads to complications such as retinopathy, nephropathy, neuropathy, and an increased risk for cardiovascular diseases.
Urinary tract A 41-year-old woman with anorexia nervosa took large quantities of saccharin and cyclamate and developed polydipsia and polyuria (urine output over 5 l/day) [5 A]. Plasma osmolality was increased (363 mOsm/kg) with a urine osmolality of 388 mOsm/kg, consistent with an osmotic diuresis.
This study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 diabetes mellitus. Material and Methods:
Sodium Cyclamate. The synthetic sweetener, sodium cyclamate, was originally designated in the list of GRAS ingredients. The liver converts sodium cyclamate to cyclohexylamine, a well-documented cause of bladder cancer in both male and female rats.
