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1. www.cancer.gov › about-cancer › causes-preventionArtificial Sweeteners and Cancer - NCI - National Cancer...

   www.cancer.gov › about-cancer › causes-prevention

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   Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.

   • Obesity and Cancer

     Obesity is a disease in which a person has an unhealthy...

   • Gastrointestinal Tract

     The organs that food and liquids travel through when they...

   • Calories

     NCI's Dictionary of Cancer Terms provides easy-to-understand...

   • Diabetes

     Any of several diseases in which the kidneys make a large...

   • Animal Studies

     A laboratory experiment using animals to study the...

   • Lymphoma

     Cancer that begins in cells of the immune system. There are...

   • World Health Organization

     A part of the United Nations that deals with major health...

   • Kidney Cancer

     Cancer that forms in tissues of the kidneys. There are many...

2. www.sciencedirect.com › sodium-cyclamateSodium Cyclamate - an overview | ScienceDirect Topics

   www.sciencedirect.com › sodium-cyclamate

   In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.

3. www.europarl.europa.eu › doceo › documentCyclamate in food poses a danger to our health - European...

   www.europarl.europa.eu › doceo › document

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   Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.

4. pmc.ncbi.nlm.nih.gov › articles › PMC10146554Impact of Long-Term Cyclamate and Saccharin Consumption on...

   pmc.ncbi.nlm.nih.gov › articles › PMC10146554

   No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).

5. academic.oup.com › toxsci › articleLong-Term Toxicity and Carcinogenicity Study of Cyclamate in...

   academic.oup.com › toxsci › article

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   1 sty 2000 · Because sodium cyclamate has been implicated as a bladder carcinogen in rodents, special attention was given to macro- and microscopic examination of the urinary bladder. No premalignant lesions of the urothelium or bladder tumors were detected in either the cyclamate or control groups.

6. www.health.harvard.edu › blog › sweeteners-time-to-rethink-your-choices-2019022215967Sweeteners: Time to rethink your choices? - Harvard Health

   www.health.harvard.edu › blog › sweeteners-time-to-rethink-your-choices-2019022215967

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   22 lut 2019 · For example, cyclamate (which was often combined with saccharin) was banned from all US food and drink products due to concerns regarding cancer risk. Saccharin's possible link to cancer led to a warning label; as additional research suggested no increased cancer risk in humans, this warning was dropped in 2000.

7. www.ncbi.nlm.nih.gov › pmc › articlesNon‐nutritive sweeteners for diabetes mellitus - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   27 lis 2017 · Description of the condition. Diabetes mellitus is a metabolic disorder impeding the pancreas from producing enough insulin, body cells from responding properly to the insulin produced, or both. This leads to chronic hyperglycaemia (i.e. elevated plasma glucose levels) and disturbances of carbohydrate, fat, and protein metabolism.