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In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [6,7].
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
In a single study, eight persons ingesting sodium cyclamate (70 mg/ kg per day) did not exhibit chromosomal aberrations in their lymphocytes 20. Calcium cyclamate induced chromosomal aberrations in bone-marrow cells of gerbils, but not in bone-marrow cells or spermatogonia of rats, treated in vivo.
Side Effects of Sodium Cyclamate. Sodium cyclamate is an artificial sweetener that's 30 times as sweet as sugar. The U.S. Food and Drug Administration banned it in 1969 due to concerns about its safety after an animal study showed a potential increased risk for cancer.
22 maj 2012 · Side Effects of Sodium Cyclamate. Sodium cyclamate is the solid form of the artificial sweetener cyclamate. Because of potential health concerns, cyclamate is currently banned by the U.S. Food and Drug Administration for consumption by humans.
