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Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [6,7].
No data were available on the genetic and related effects of calcium cyc1amate, dicyclohexylamine or cyclohexylamine in humans. In a single study, eight persons ingesting sodium cyclamate (70 mg/ kg per day) did not exhibit chromosomal aberrations in their lymphocytes 20 .
28 sie 2024 · Some people may feel bad or experience negative effects after consuming artificial sweeteners, even though they are safe and well tolerated by most people.
13 gru 2016 · Polyol bulk sweeteners have a laxative effect in humans and animals when consumed in excessive doses, owing to the osmotic effects of unabsorbed polyols reaching the colon. Polyols differ in their potency to cause laxation.
