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Conclusion: Consumption of saccharin and cyclamate affected biochemical parameters related to metabolic functions in a time and dose-dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.
In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies.
Sodium cyclamate is used as an NNS, and the analogous calcium salt is used especially in low-sodium diets. Cyclamate is 30 times sweeter than sucrose. It has a bitter aftertaste but has good sweetness synergy with saccharin. It is soluble in water and its solubility can be increased by preparing the sodium or calcium salt.
The European Acceptable Daily Intake (ADI) standard provides for a maximum of 7 milligrammes of cyclamate per day per kilogramme of body weight for children up to the age of eight.
27 lis 2017 · Cyclamate (cyclamic acid) is used as an NNS in two forms: sodium cyclamate and calcium cyclamate. It is 30 times sweeter than sucrose and contains zero calories (Chattopadhyay 2014).
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
Cyclamate (INS 952, E 952) is a calorie-free sweetener discovered in 1937. It is 30 to 50 times sweeter than sucrose. Cyclamate is metabolised to a limited extent by the bacteria in the lower gut by some individuals; limited absorption by the body.
