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Conclusion: Consumption of saccharin and cyclamate affected biochemical parameters related to metabolic functions in a time and dose-dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
1 sty 2000 · The overall conclusion is that the testicular abnormalities and the sporadic cases of different malignancies found after more than 20 years of dosing do not provide clear evidence of a toxic or carcinogenic effect of sodium cyclamate in monkeys.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
It is a salt of cyclohexylsulfamic acid. Sodium cyclamate is used as an NNS, and the analogous calcium salt is used especially in low-sodium diets. Cyclamate is 30 times sweeter than sucrose. It has a bitter aftertaste but has good sweetness synergy with saccharin.
6 wrz 2020 · Learn more the artificial sweetener - Sodium Cyclamate (E952) from production; compare with calcium cyclamate; uses; safety; side effects.
