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2 lip 2022 · We propose that interfering cellular pH by bicarbonate could induce a cascade of molecular events leading to cancer cell death.
13 wrz 2022 · There are two main therapeutic approaches that target the acidic pH of the TME. One is buffer therapy, in which alkalizing agents are administered to neutralize protons, and the other is the inhibition of proton efflux transporters expressed on the cancer cell membrane (Figure 1).
1 gru 2021 · In recent years, sodium bicarbonate (NaHCO 3), a simple inorganic salt, has been found to be able to reverse the pH of tumor microenvironment and inhibit the invasion, metastasis, immune evasion, drug resistance and hypoxia of tumor cells.
20 mar 2019 · Sodium bicarbonate would not be a feasible cancer treatment because it is not well-tolerated by humans, but other approaches that lower acidity could be worth exploring, Gertler says.
1 wrz 2020 · Robey et al. showed that sodium bicarbonate decreased extravasation of circulating cancer cells decreasing metastatic risk of certain tumors in experimental conditions.
18 cze 2020 · The treatment of the animals with sodium bicarbonate reduced the pH gradient and reduced the local invasion in these tumour models .
1 mar 2012 · Metastasis inhibition through tumour buffering has been confirmed experimentally through oral administration of sodium bicarbonate (NaHCO 3, pKa 6.3) to severe combined immunodeficient mice ...
