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2 wrz 2022 · First, we investigated the association between smoking-related phenotypes (lifetime amount of smoking, and ever having smoked regularly) and subsequent endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank.
Several studies have examined the association between smoking and endometrial-cancer risk according to factors that are known determinants of endogenous hormone concentrations, and which may counteract or augment possible tobacco-related hormonal changes. These factors include menopausal status, use of HRT, and relative bodyweight.
Smoking cessation 1–4 years prior to baseline was significantly associated with endometrial carcinoma risk (RR 0.65, 95 % CI 0.48, 0.89), while cessation ≥10 years before baseline was not.
Our meta-analysis has assessed the relation between cigarette smoking and endometrial cancer risk. Overall, smoking was statistically significantly associated with 18% and 29% reduced risks of endometrial cancer in prospective and case-control studies, respectively.
In the premenopausal group, women currently exposed to tobacco smoke either by active or passive smoking has a non significant increased risk of endometrial cancer (HR = 1.56, 95% CI = 0.82–3.03 for active current smokers and HR = 1.31, 95% CI = 0.74–2.34 for passive smokers).
The evidence in this study suggests a reduction of about 50 per cent in the risk of endometrial cancer for women who smoke at least 25 cigarettes per day.
factors as being associated or not associated with the risk of endometrial cancer. This information aims to improve understanding of the current state of the evidence relating to risk and protective factors for endometrial cancer.
