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2 wrz 2022 · First, we investigated the association between smoking-related phenotypes (lifetime amount of smoking, and ever having smoked regularly) and subsequent endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank.
Download PDF. Summary. Epidemiological studies have shown that cigarette smoking is associated with a reduced risk of endometrial cancer, in contrast to the increased risks observed with many other non-respiratory-tract cancers, including those of the bladder, pancreas, and cervix uteri.
Our meta-analysis has assessed the relation between cigarette smoking and endometrial cancer risk. Overall, smoking was statistically significantly associated with 18% and 29% reduced risks of endometrial cancer in prospective and case-control studies, respectively.
The consistency of risk estimates across strata of endometrial carcinoma risk factors may indicate that cigarette smoking lowers endometrial carcinoma risk through a common mechanism regardless of other characteristics related to endometrial carcinogenesis.
Many factors affect the risk of developing endometrial cancer, including: Obesity. Things that affect hormone levels, like taking estrogen after menopause, birth control pills, or tamoxifen; the number of menstrual cycles (over a lifetime), pregnancy, certain ovarian tumors, and polycystic ovarian syndrome (PCOS) Use of an intrauterine device (IUD)
In the premenopausal group, women currently exposed to tobacco smoke either by active or passive smoking has a non significant increased risk of endometrial cancer (HR = 1.56, 95% CI = 0.82–3.03 for active current smokers and HR = 1.31, 95% CI = 0.74–2.34 for passive smokers).
The evidence in this study suggests a reduction of about 50 per cent in the risk of endometrial cancer for women who smoke at least 25 cigarettes per day.
