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7 lut 2023 · Smallpox generally resulted in acute onset of fever and malaise, followed by a distinctive skin rash mainly occurring on the face, arms, and legs. It was mainly transmitted between humans through the respiratory route via saliva droplets; however, transmission from direct contact with infected bodily fluids was also reported. [1]
5 sie 2022 · Smallpox is a serious and often deadly viral infection. It's contagious — meaning it spreads from person to person — and can cause permanent scarring. Sometimes, it causes disfigurement. Smallpox has affected humans for thousands of years but was wiped out worldwide by 1980 thanks to smallpox vaccines.
5 sie 2022 · Treatment. If someone were infected with smallpox, new antiviral medications may be used. Tecovirimat (Tpoxx). The U.S. Food and Drug Administration (FDA) approved this drug for use in the U.S. in 2018. Research found that it worked in animals and in lab tests. However, it hasn't been tested in people who are sick with smallpox.
Print. This information is about preventing or responding to smallpox. For the latest information about the current mpox outbreak, including information on symptoms, prevention, and vaccines, please visit CDC’s Mpox site. There are vaccines to protect people from smallpox.
Brincidofovir. In June 2021, the FDA approved brincidofovir (also referred to its brand name TEMBEXA) for treatment of smallpox. Brincidofovir’s effectiveness against smallpox was established with in vitro studies using related orthopoxviruses as well as variola.
There are four main clinical forms of smallpox, each with different characteristics. During the smallpox era, the case-fatality rate differed for the different clinical forms, but it was approximately 30% overall in unvaccinated individuals.
8 sie 2023 · Continuing Education Activity. Smallpox is the first human infectious disease to be successfully eradicated worldwide. It remains of clinical concern because of the potential for release and weaponization. Smallpox is a member of the viral family poxvirus, genus orthopoxvirus, and species variola virus.
